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KMID : 0861020110260010087
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Korea Journal of Herbology
2011 Volume.26 No. 1 p.87 ~ p.96
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Anti-oxidative and anti-inflammatory effects of aerial parts of Rumex japonicus Houtt. in RAW 264.7 cells
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Cho Hyun-Jin
Yun Hyun-Jeong
Park Sun-Dong
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Abstract
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Objectives: The aerial parts of Rumex japonicus Houtt. (RF) is used by traditional clinics to treat parasite infection in East asia. This study aims a verification of anti-oxidative and anti-inflammatory effects of RF methanol extract.
Methods: Anti-oxidative effects of RF were measured by scavenging activities of DPPH, superoxide, nitric oxide (NO) and peroxynitrite radicals. And also scavenging activities of anti-oxidation in lipopolysaccharide (LPS)-treated RAW 264.7 cells were measured. The inhibitory effects against the production of inflammatory mediators including NO, prostaglandin E₂ (PGE₂), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and the translocation of nuclear factor (NF)-xB in LPS-stimulated RAW 264.7 cells by RF were tested.
Results:RF scavenged DPPH, superoxide, NO and peroxynitrite radicals, and RF (at 200㎍/㎖) reduced the inflammatory mediators definitely.
Conclusions : These results indicate that RF may be a potential drug source for oxidative stress related inflammatory diseases.
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KEYWORD
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The aerial parts of Rumex japonicus Houtt. (RF), Anti-inflammation, Anti-oxidation, RAW264.7 cell Introduction
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